Table 4 Training group: ROC correlation analysis and comparison of DP-ACLF and other prognostic scores at the third day, first week and second week after admission.

From: A dynamic prediction model for prognosis of acute-on-chronic liver failure based on the trend of clinical indicators

Time point (cases, n)

Variable

AUC (95% CI)

St

Cut-off value

Sensitivity

Specificity

*z statistic (p value)

The third day after admission (n = 533)

CTP (3rd day)

0.632 (0.590–0.673)

0.024

12

0.583

0.617

5.595 (p < 0.001)

MELD (3rd day)

0.756 (0.717–0.791)

0.023

25

0.680

0.746

2.171 (p = 0.030)

MELD-Na (3rd day)

0.733 (0.694–0.770)

0.023

26

0.743

0.620

2.975 (p = 0.003)

CLIF-SOFA (3rd day)

0.697 (0.656–0.736)

0.023

8

0.691

0.589

4.209 (p < 0.001)

CLIF-C ACLF (3rd day)

0.693 (0.652–0.732)

0.024

39

0.857

0.480

3.944 (p < 0.001)

COSSH-ACLF (3rd day)

0.706 (0.665–0.744)

0.023

6

0.817

0.500

3.549 (p < 0.001)

DP-ACLF (3rd day)

0.787 (0.749–0.821)

0.021

9.7

0.760

0.710

NA

The first week after admission (n = 511)

CTP (1st week)

0.642 (0.598–0.683)

0.025

11

0.824

0.427

5.229 (p < 0.001)

MELD (1st week)

0.760 (0.721–0.797)

0.024

23

0.732

0.704

1.702 (p = 0.089)

MELD-Na (1st week)

0.752 (0.712–0.789)

0.023

25

0.811

0.620

1.796 (p = 0.073)

CLIF-SOFA (1st week)

0.572 (0.528–0.615)

0.027

9

0.288

0.830

6.514 (p < 0.001)

CLIF-C ACLF (1st week)

0.703 (0.661–0.742)

0.025

44

0.556

0.771

3.446 (p < 0.001)

COSSH-ACLF (1st week)

0.703 (0.662–0.743)

0.024

6

0.582

0.754

3.614 (p < 0.001)

DP-ACLF (1st week)

0.788 (0.750–0.823)

0.021

10

0.673

0.785

NA

The second week after admission (n = 490)

CTP (2nd week)

0.691 (0.648–0.732)

0.025

11

0.818

0.534

6.044 (p < 0.001)

MELD (2nd week)

0.779 (0.739–0.815)

0.024

24

0.689

0.799

2.482 (p = 0.013)

MELD-Na (2nd week)

0.759 (0.718–0.796)

0.023

23

0.833

0.584

3.017 (p = 0.003)

CLIF-SOFA (2nd week)

0.728 (0.687–0.767)

0.024

8

0.667

0.682

5.230 (p < 0.001)

CLIF-C ACLF (2nd week)

0.729 (0.687–0.768)

0.025

42

0.667

0.740

4.814 (p < 0.001)

COSSH-ACLF (2nd week)

0.712 (0.669–0.752)

0.025

6

0.697

0.651

5.089 (p < 0.001)

DP-ACLF (2nd week)

0.823 (0.786–0.856)

0.020

9.4

0.833

0.698

NA

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