Table 2 Univariable Cox proportional hazards analysis of the risk of recurrence.
Patient characteristics | TCGA-HCC test cohort (n = 53) | Stanford-HCC (n = 198) | ||
|---|---|---|---|---|
Internal test set | External test set | |||
Hazard ratio (95% CI) | p value | Hazard ratio (95% CI) | p value | |
Risk score (binarized) | 6.52 (1.83, 23.2) | 0.0038 | 3.72 (2.17, 6.37) | < 0.0001 |
Age (at surgery) | ||||
> 60 years | 0.83 (0.38, 1.8) | 0.65 | 1.1 (0.64, 1.8) | 0.77 |
Gender | ||||
Female | 0.99 (0.44, 2.2) | 0.98 | 0.99 (0.53, 1.9) | 0.98 |
Hepatitis B virus infection | ||||
Positive | 0.57 (0.22, 1.5) | 0.25 | 1.1 (0.62, 1.9) | 0.78 |
Hepatitis C virus infection | ||||
Positive | 1.2 (0.4, 3.6) | 0.74 | 0.66 (0.4, 1.1) | 0.11 |
Alcohol intake | ||||
Positive | 0.89 (0.37, 2.2) | 0.80 | 0.19 (0.027, 1.4) | 0.10 |
Non-alcoholic fatty liver disease | ||||
Positive | 1.6 (0.46, 5.4) | 0.48 | 1.8 (0.81, 3.9) | 0.15 |
AJCC stage grouping | ||||
> II | 1.3 (0.49, 3.6) | 0.58 | 4.4 (2.3, 8.3) | < 0.0001 |
Largest tumor diameter (mm) | ||||
> 50 | 1.1 (0.52, 2.5) | 0.74 | 3.5 (2.1, 5.8) | < 0.0001 |
Tumor multifocality | ||||
Positive | 1.3 (0.53, 3.4) | 0.53 | 1.1 (0.64, 1.9) | 0.71 |
Histologic grade | ||||
> Moderately-differentiated | 1.1 (0.44, 2.6) | 0.90 | 2.1 (1.2, 3.9) | 0.013 |
Microvascular invasion | ||||
Positive | 1.4 (0.6, 3.1) | 0.46 | 3.9 (2.4, 6.5) | < 0.0001 |
Macrovascular invasion | ||||
Positive | 1.6 (0.46, 5.4) | 0.48 | 5.3 (2.1, 1.3) | 0.00043 |
Surgical margin | ||||
Positive | 0.74 (0.22, 2.5) | 0.63 | 6.8 (1.6, 28) | 0.0090 |
Fibrosis stage | ||||
> 2 | 2.7 (0.98, 7.7) | 0.054 | 0.33 (0.2, 0.55) | < 0.0001 |
