Table 1 Descriptive analysis of semen quality and markers of DNA damage and DNA methylation.
From: The marker of alkyl DNA base damage, N7-methylguanine, is associated with semen quality in men
Variable | Value | Mean ± SD (n) | Range |
|---|---|---|---|
Age | Years | 35.3 ± 5.8 (105) | 26–57 |
Semen quality | Sperm concentration (× 106/ml) | 59.1 ± 66.2 (105) | 0.5–362.0 |
Progressive motile sperm (%) | 49.0 ± 17.1 (105) | 1.0–77.0 | |
Immobile sperm (%) | 40.9 ± 14.5 (105) | 0.5–99.0 | |
Semen volume (ml) | 3.2 ± 1.4 (105) | 0.5–8.1 | |
Comet assay | Median tail DNA (%) | 1.02 ± 0.76 (105) | 0.07–5.28 |
Sperm with low DNA damage (LDD) (%) | 15.4 ± 8.3 (105) | 2.3–39.2 | |
Sperm with high DNA damage (HDD) (%) | 14.7 ± 8.6 (105) | 4.0–47.2 | |
N7-MedG | fmoles/μg DNA | 0.55 ± 0.35 (101) | 0.12–2.30 |
Global methylation | nM | 396.1 ± 71.3 (44) | 296–687 |
Gene Methylation | DAZL (% methylated) | 4.6 ± 5.0 (31) | 0.4–20.0 |
H19 (% methylated) | 40.4 ± 11.9 (44) | 12.8–73.0 | |
MEG3 (% methylated) | 77.4 ± 27.8 (45) | 0–91.3 | |
SNRPN (% methylated) | 3.2 ± 2.5 (43) | 0.7–12.3 |
