Table 5 Unadjusted and adjusteda associations between DNA damage marker and poor semen quality categorised by WHO reference values.

From: The marker of alkyl DNA base damage, N7-methylguanine, is associated with semen quality in men

DNA damage marker

OR (95%CI)

Semen volume

Concentration

Progressive motility

Any category

Unadjusted

Unadjusted

Adjusted

Unadjusted

Adjusted

Unadjusted

Adjusted

N7MedG

7.2 (1.7–30.0)

6.46 (1.51–27.7)

6.42 (1.47–28.0)

2.80 (0.79–9.91)

3.42 (0.89–13.2)

20.7 (2.75–155.6)

19.0 (2.41–150)

% LDD spermb

-

-

-

0.91 (0.84–0.98)

0.98 (0.87–1.10)

0.93 (0.88–0.98)

1.03 (0.94–1.13)

% HDD spermc

-

1.06 (1.01–1.12)

0.99 (0.90–1.08)

1.12 (1.05–1.20)

1.09 (0.97–1.22)

1.10 (1.04–1.17)

1.01 (0.92–1.12)

% Tail DNA

-

2.48 (1.26–4.86)

2.33 (0.75–7.31)

4.54 (1.89–10.9)

1.54 (0.23–10.2)

4.90 (2.03–11.8)

5.17 (0.8–33.2)

  1. aAdjusted for other markers of DNA damage that were significantly associated with semen quality in a univariate analysis; b % sperm with low DNA damage;c % sperm with high DNA damage.
Back to article page