Table 2 The 20 top-ranked DNA methylation sites in the AOD versus HC group (a) and the LOD versus HC group (b).

ID	Fisher Ratio	HC average	AOD average	CHR	MAPINFO	UCSC_REFGENE_NAME	UCSC_REFGENE_GROUP	RELATION_TO_UCSC_CPG_ISLAND
(a)
cg15794987	3.85	0.954	0.937	8	6,534,897
cg07763047	3.71	0.046	0.025	5	160974837	GABRB2;GABRB2	5′UTR;5′UTR	Island
cg21347377	3.59	0.014	0.006	10	96,305,691	HELLS	1stExon	Island
cg17458347	3.53	0.099	0.083	1	42,928,946			Island
cg14567489	3.41	0.021	0.014	20	43,977,078	SDC4	TSS200	Island
cg02221310	3.33	0.013	0.004	13	41,363,578	SLC25A15;SLC25A15	5′UTR;1stExon	Island
cg16579770	3.29	0.934	0.917	16	72,058,938	DHODH	3′UTR
cg01320648	3.22	0.548	0.517	4	123091375	KIAA1109	TSS1500
cg05974695	3.19	0.026	0.017	11	130786536	SNX19	TSS200	Island
cg15525503	3.13	0.020	0.008	1	3,773,166	DFFB;KIAA0562	TSS1500;5′UTR	N_Shore
cg26655295	3.08	0.045	0.034	2	677,162	TMEM18	Body	Island
cg12867237	3.07	0.146	0.128	11	44,087,540	ACCS;ACCS	TSS200;TSS1500	Island
cg16234726	3.06	0.937	0.922	14	102099176			N_Shore
cg20452738	3.04	0.922	0.947	1	226828650	ITPKB	Body	N_Shore
cg23543123	2.99	0.023	0.013	4	48,485,569	SLC10A4;SLC10A4	5′UTR;1stExon	Island
cg22115465	2.91	0.983	0.979	7	2,170,343	MAD1L1;MAD1L1;MAD1L1	Body;Body;Body
cg04147027	2.90	0.030	0.022	6	82,462,442	FAM46A	TSS200	Island
cg15971980	2.89	0.571	0.676	6	150254442
cg24934561	2.89	0.064	0.055	1	3,663,902	KIAA0495	TSS200	Island
cg23531049	2.81	0.845	0.892	15	42,075,277	MAPKBP1;MAPKBP1	Body;Body

ID	Fisher Ratio	HC average	LOD average	CHR	MAPINFO	UCSC_REFGENE_NAME	UCSC_REFGENE_GROUP	RELATION_TO_UCSC_CPG_ISLAND
(b)
cg06557376	3.14	0.959	0.949	17	8,384,607	MYH10	Body
cg23854456	2.87	0.936	0.920	19	39,806,075	LRFN1	TSS200	S_Shore
cg09597022	2.46	0.884	0.855	6	33,288,332	DAXX;DAXX;DAXX;DAXX	Body;Body;Body;Body	N_Shore
cg04521026	2.21	0.958	0.948	2	240067196	HDAC4	Body
cg15390741	2.06	0.986	0.976	1	51,822,535	EPS15;EPS15	Body;Body
cg06034437	2.03	0.521	0.474	3	10,183,196	VHL;VHL	TSS200;TSS200	N_Shore
cg25996553	1.99	0.889	0.869	8	13,133,084	DLC1	Body	N_Shore
cg18394552	1.92	0.648	0.577	5	159428643
cg04262179	1.89	0.975	0.971	1	178482030	C1orf49;C1orf49;C1orf49;C1orf49	TSS200;TSS200;TSS200;TSS200
cg03473408	1.88	0.769	0.696	6	30,588,689	MRPS18B	Body	S_Shelf
cg27318635	1.83	0.949	0.937	16	3,781,749	CREBBP;CREBBP	Body;Body	S_Shore
cg16011480	1.78	0.151	0.139	10	97,667,594	C10orf131	TSS200	Island
cg27088822	1.75	0.799	0.752	12	121731226	CAMKK2;CAMKK2;CAMKK2;CAMKK2;CAMKK2;CAMKK2;CAMKK2	5′UTR;5′UTR;5′UTR;5′UTR;5′UTR;5′UTR;5′UTR	N_Shelf
cg13081381	1.72	0.480	0.502	13	82,264,192
cg01345727	1.71	0.759	0.695	13	52,734,018	NEK3;NEK3;NEK3;NEK3	TSS1500;TSS200;TSS200;TSS200	S_Shore
cg11855759	1.70	0.205	0.234	17	9,548,802	USP43	TSS200	Island
cg22389270	1.70	0.263	0.244	8	101162769	POLR2K	TSS200
cg11558107	1.69	0.932	0.912	15	60,700,124
cg20420249	1.66	0.808	0.758	1	172378938	DNM3;DNM3	3′UTR;3′UTR
cg15587947	1.66	0.861	0.844	19	10,220,948	PPAN-P2RY11;P2RY11;PPAN	Body;TSS1500;Body	Island

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