Table 2 MVD, pMVD, GMP by clinico-pathologic variables and molecular subtypes of breast cancer.

From: Baseline microvessel density predicts response to neoadjuvant bevacizumab treatment of locally advanced breast cancer

 

MVD, N = 128

pMVD, N = 128

GMP, N = 130

≥ Median

≥ Median

Present

N

%

OR

95% CI

P

N

%

OR

95% CI

P

N

%

OR

95% CI

P

Estrogen receptor

Positive

53

50

Ref

  

54

51

Ref

  

9

8

Ref

  

Negative

12

57

1.4

0.5–3.5

NS

18

86

5.9

1.6–21.2

0.003

5

24

3.5

1.0–11.7

0.051a

Progesterone receptor

Positive

37

47

Ref

  

38

49

Ref

  

6

8

Ref

  

Negative

28

56

1.4

0.7–2.9

NS

34

68

2.2

1.1–4.7

0.032

8

16

2.3

0.7–7.0

NS

Triple negative

Absent

54

50

Ref

  

54

50

Ref

  

9

8

Ref

  

Present

11

55

1.2

0.5–3.2

NS

18

90

9.0

2.0–40.7

0.001

5

25

3.7

1.1–12.7

0.041a

Tumor stage

T2

14

37

Ref

  

18

47

Ref

  

6

16

Ref

  

T3

47

59

2.4

1.1–5.4

0.026

46

58

1.5

0.7–3.3

NS

4

5

0.3

0.1–1.0

0.073a

Histologic grade

1–2

45

48

Ref

  

49

53

Ref

  

6

6

Ref

  

3

15

56

1.3

0.6–3.2

NS

20

74

2.6

1.0–6.6

0.048

8

30

6.2

1.9–19.9

0.003a

Molecular subtype

Luminal A

25

47

   

20

38

   

2

4

   

Luminal B

20

50

   

24

60

   

3

8

   

HER2-enriched

3

33

   

6

67

   

3

33

   

Basal-like

14

70

   

19

95

   

6

30

   

Normal breast-like

2

40

  

NSa

2

40

  

< 0.0005a

0

0

  

0.004a

Basal-like

Absent

50

47

Ref

  

52

49

Ref

  

8

7

Ref

  

Present

14

70

2.7

1.0–7.4

0.056

19

95

20.1

2.6–156

< 0.0005

6

30

5.4

1.6–17.9

0.009a

  1. Tumor stage: T4 tumors were excluded from the analyses. T2: 2,5- < 5 cm and T3: ≥ 5 cm in diameter. MVD and pMVD; N = 128, GMP; N = 130. Missing data: histologic grade: N = 8 (MVD and pMVD analyses) N = 7 (GMP analyses); molecular subtype: N = 1.
  2. MVD microvessel density, pMVD proliferative microvessel density, GMP glomeruloid microvascular proliferation, N number of patients, OR odds ratio, CI confidence interval, P p values by Pearson’s chi-square test.
  3. aFisher’s exact test.
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