Table 2 Representative SNPs identified by GWAS among the significant loci for model 1 (MHNW versus MUHNW) and model 2 (MHO versus MUHO).

Gene	Region	Chr	Position (bp)	SNP	SNP cluster	Minor allele	MAF	OR (95% CIs)	p-value
2–1. MHNW (control) versus MUHNW (case)
GCKR	Intron variant	2	27 734 972	rs6547692	rs780096, rs1260326	A	0.46	0.90 (0.87–0.94)	1.27E-08
ABCB11	Intron variant	2	169 803 568	rs16856261	rs3755157, rs58512362	T	0.37	1.12 (1.08–1.16)	2.07E-09
CDKAL1	Intron variant	6	20 693 697	rs138420022	rs34499031, rs35261542	A	0.47	1.15 (1.11–1.19)	1.09E-14
LPL	Downstream gene variant	8	19 865 455	rs77237194	rs10096633, rs17482753	T	0.12	0.83 (0.78–0.87)	2.56E-12
CDKN2B	Downstream gene variant	9	22 132 729	rs10965247	rs10811660, rs10965246	G	0.44	0.89 (0.86–0.92)	1.27E-10
NT5C2	Downstream gene variant	10	104 960 464	rs113278154	rs79237883, rs34747231	T	0.27	0.90 (0.86–0.92)	4.37E-08
APOA5	Upstream gene variant	11	116 662 579	rs651821	rs662799, rs2075291	C	0.30	1.47 (1.42–1.53)	1.68E-90
CETP	Intron variant	16	57 002 663	rs9926440	rs17231506, rs821840	C	0.31	1.16 (1.11–1.20)	2.95E-14
APOC1	Intron variant	19	45 420 082	rs73052335	rs111789331, rs66626994	C	0.10	1.24 (1.17–1.32)	1.24E-13
2–2. MHO (control) versus MUHO (case)
LPL	Downstream gene variant	8	19 827 848	rs10105606	rs1441766, rs4464984	A	0.12	0.83 (0.78–0.87)	1.68E-11
APOA5	Upstream gene variant	11	116 662 579	rs651821	rs662799	C	0.30	1.43 (1.36–1.51)	8.55E-44
CETP	Upstream gene variant	16	56 993 886	rs821840	rs36229491, rs17231506	G	0.17	0.83 (0.78–0.88)	2.02E-10

Logistic regression models were adjusted for age, sex, exercise status, smoking status, alcohol intake, body mass index, and PC1 and PC2.
GWAS, genome-wide association study; MHNW, metabolically healthy normal weight; MUHNW, metabolically unhealthy normal weight; MHO, metabolically healthy obese; MUHO, metabolically unhealthy obese; Chr, chromosome; SNP, single-nucleotide polymorphism; MAF, minor allele frequency; OR, odds radio; CI, confidence interval.

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