Table 2 Univariate and multivariate Cox models of DFS for different variables and rs2234693.
From: The variant T allele of PvuII in ESR1 gene is a prognostic marker in early breast cancer survival
DFS | Frequency | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | ||
Age | 805 | 0.997 | 0.980–1.015 | 0.763 | |||
BMI | 805 | 0.984 | 0.951–1.019 | 0.360 | |||
T stage | |||||||
T1 | 367 (45.7) | ||||||
T2-4 | 436 (54.3) | 2.002 | 1.434–2.796 | 0.00005 | 1.833 | 1.258–2.671 | 0.002 |
N stage | |||||||
N0 | 237 (29.5) | ||||||
N + | 566 (70.5) | 1.198 | 0.842–1.704 | 0.315 | |||
PR status | |||||||
Positive | 590 (77.1) | ||||||
Negative | 175 (22.9) | 1.684 | 1.198–2.367 | 0.003 | 1.716 | 1.120–2.434 | 0.002 |
Histological grade (BR) | |||||||
1 | 143 (18.7) | 1.000 | 0.094* | 1.000 | 0.150* | ||
2 | 369 (48.4) | 1.712 | 1.038–2.824 | 1.673 | 0.989–2.831 | ||
3 | 251 (32.9) | 1.691 | 1.002–2.854 | 1.621 | 0.931–2.821 | ||
Most extensive surgery | |||||||
Wide local excision | 372 (46.2) | ||||||
Mastectomy | 433 (53.8) | 1.742 | 1.258–2.413 | 0.001 | 1.527 | 1.057–2.206 | 0.024 |
Adjuvant chemotherapy | |||||||
No | 589 (74.3) | ||||||
Yes | 216 (26.8) | 0.969 | 0.677–1.387 | 0.865 | |||
Adjuvant radiotherapy | |||||||
No | 487 (60.5) | ||||||
Yes | 318 (39.5) | 0.846 | 0.619–1.156 | 0.294 | |||
rs2234693 (ESR1, PvuII) | |||||||
CC | 149 (18.4) | 1.000 | 0.105* | ||||
CT | 361 (51.1) | 0.656 | 0.445–0.969 | ||||
TT | 200 (28.1) | 0.751 | 0.487–1.158 | ||||
CC | 149 (21.0) | 1.000 | 1.000 | ||||
TT/CT | 561 (79.0) | 0.689 | 0.480–0.989 | 0.044 | 0.696 | 0.469–1.031 | 0.071 |
