Figure 1 | Scientific Reports

Figure 1

From: iPSC-derived cardiomyocytes from patients with myotonic dystrophy type 1 have abnormal ion channel functions and slower conduction velocities

Figure 1

Immunofluorescence staining of cardiac markers in iPSC-CMs after 30 days of maturation. iPSC-CMs from the CTRL individual and the DM1-300 and DM1-1300 patients showed organized contractile proteins, including myosin light chain2v (mlc2v, green staining), cardiac troponin T (cTnT, red staining), and the cardiac sodium channel (NaV1.5, blue staining). The last column shows merged images from mlc2v, cTnT, and NaV1.5. The insets show a zoom-in of the stained proteins. Scale bar: 20 µM. Images were acquired using Zeiss ImagerM2 LSM confocal microscope and processed with ZEN software (Zeiss).

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