Figure 5 | Scientific Reports

Figure 5

From: iPSC-derived cardiomyocytes from patients with myotonic dystrophy type 1 have abnormal ion channel functions and slower conduction velocities

Figure 5

APD prolongation revealed by patient-specific iPSC-CMs. (A) Representative AP traces of atrial, ventricular, and nodal-like cells recorded in CTRL, DM1-300, and DM1-1300 iPSC-CMs. (B) Bar graph summarizing the APD at 20%, 50%, or 90% of repolarization in atrial-like (n = 19–21), (C) ventricular-like (n = 12–25), and (D) nodal like (n = 14–21) cells at a stimulation frequency of 1 Hz. Bars indicate SEM. **p < 0.01, ***p < 0.001 (CTRL vs DM1-1300) and #p < 0.05, ###p < 0.001 (DM1-300 vs DM1-1300) as determined by ANOVA and Turkey’s post hoc test.

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