Figure 6
Action potentials dV/dt and overshoot are affected in DM1 iPSC-CMs. (A) Close-up view on the rising phase of representative APs recorded at a stimulation frequency of 1 Hz. (B) Bar graphs showing the maximal upstroke velocity (dV/dtmax) and overshoot (C) of APs recorded in atrial-like (n = 21–23), ventricular-like (n = 12–25), and nodal-like (n = 14–21) cells at a stimulation frequency of 1 Hz. Bars indicate SEM. *p < 0.05, ***p < 0.001 (CTRL vs DM1-1300) and ##p < 0.01, ###p < 0.001 (DM1-300 vs DM1-1300) as determined by ANOVA and Turkey’s post hoc test.
