Figure 3 | Scientific Reports

Figure 3

From: In-depth quantitative proteomic characterization of organotypic hippocampal slice culture reveals sex-specific differences in biochemical pathways

Figure 3

Glutathione metabolism. Proteomic analysis revealed prevalence of GSH synthesis and consumption in female hippocampus. The glutathione redox cycling catalyzed by GPx and GR is dependent on NADPH as a supplier of reducing equivalents, constantly regenerated mainly by pentose phosphate pathway. The differentially expressed proteins revealed by proteomics in organotypic hippocampal slice culture are highlighted in pink (increased abundance in female) and blue (increased abundance in males). For more details, see Supplementary Dataset 4. Statistical analyses were performed by using Student's t test followed by multiple testing corrections using the Benjamini–Hochberg procedure for false discovery rate (n = 5 biological replicates, each containing 3 slices).

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