Figure 4

Molecular interaction network of proteins differently abundant between females and males underlying neurotransmission pathways and synapse function. Node colors indicate increased abundant proteins in female (pale pink) and male (blue) hippocampus, and node size indicates different levels of fold changes relative to each individual network. Protein–protein interaction analysis of significantly changed proteins in the hippocampus was obtained using STRING and then mapped by using Cytoscape 3.7.1. For more details, see Supplementary Dataset 3. Statistical analyses were performed by using Student's t test followed by multiple testing corrections using the Benjamini–Hochberg procedure for false discovery rate (n = 5 biological replicates, each containing 3 slices).