Figure 6

Network analysis of differently abundant proteins annotated to cellular process pathways according KEGG pathway database. Using StringApp, a Cytoscape app, functional enrichment analyzes were retrieved from the whole STRING network of cellular processes entries classified according to BlastKOALA. A subset of networks resulted from the enriched terms endocytosis (orange contour), lysosome (green contour), peroxisome (pink contour) and phagosome (purple contour). Node colors indicate increased abundant proteins in female (pale pink) and male (blue) hippocampus and node size indicates different levels of fold change relative to each individual network. For more details, see Supplementary Dataset 2. Statistical analyses were performed by using Student's t test followed by multiple testing corrections using the Benjamini–Hochberg procedure for false discovery rate (n = 5 biological replicates, each containing 3 slices).