Table 1 Characteristics of participants in the Cape Town cohort.

From: T cell-tropic HIV efficiently infects alveolar macrophages through contact with infected CD4+ T cells

 

Healthy control

Viremic HIV

Number (male/female)

14 (5/9)

15 (2/13)

Age

24.5 (21–26.75)

32 (30–34.5)*

Smokers

35.70%

0%*

Plasma viral load (copies per mL)

N/A

6383 (619–12,097)

BAL viral load (copies per mL ELF)

N/A

5546 (1036–28,034)

CD4 + T cells per μl

902 (801–1159)

571 (544–676)*

Purity of adhered AMs (%)

100 (99–100)

99 (98–100)

  1. All participants were antiretroviral therapy-naive and were sensitized to Mycobacterium tuberculosis as determined by QuantiFERON TB Gold test without clinical or radiographic evidence of active TB. BAL, bronchoalveolar lavage; ELF, epithelial lining fluid; AM, alveolar macrophage. Values are expressed as median with interquartile range. Statistical analysis was performed with Mann–Whitney test, except for smokers, where Fisher’s exact test was performed. *p < 0.05 compared to healthy controls.
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