Figure 6
From: Calcium calmodulin kinase II activity is required for cartilage homeostasis in osteoarthritis
CaMKII inhibition enhanced the capacity of IL1B to upregulate catabolic enzymes in the articular chondrocytes. (a–h) mRNA expression of ADAMTS4/5 and MMP3/13 measured by qPCR of bovine articular chondrocytes stimulated for 24 h with IL1B (20 ng/ml) in presence or absence of KN93 or its inactive analogue KN92 (both 10 µM) (a,c,e,g) or in the presence or absence of the CaMKII inhibitor AIP (b,d,f,h) (5 µM). Data were analysed with 2 ways ANOVA and Tukey post-test. n = 3.
