Table 11 Descriptive statistics from the dataset used.

From: A multilayer multimodal detection and prediction model based on explainable artificial intelligence for Alzheimer’s disease

 

CN (n = 294)

sMCI (n = 254)

pMCI (n = 232)

AD (n = 268)

Combined (n = 1048)

Gender (M/F)

140 ± 154

144/110

136/96

151 ± 117

571/477

Age (years)

74.120 ± 5.890

72.202 ± 07.553

73.771 ± 7.0840

75.241 ± 7.610

73.864 ± 07.107

Education (years)

16.405 ± 2.733

15.9530 ± 2.867

15.784 ± 2.7830

15.175 ± 2.923

15.844 ± 02.858

FAQ

0.1940 ± 0.720

01.539 ± 02.817

5.7110 ± 4.8680

13.146 ± 6.814

05.053 ± 06.754

MMSE

29.085 ± 1.143

27.941 ± 01.722

26.7590 ± 1.736

23.235 ± 2.015

26.797 ± 2.7960

MOCA

25.569 ± 1.866

23.493 ± 02.452

20.947 ± 01.908

17.553 ± 3.377

21.993 ± 3.9450

FDG

6.5690 ± 0.477

06.3820 ± 0.599

05.800 ± 00.462

5.4060 ± 0.614

6.0560 ± 0.7180

APOE4

0.2520 ± 0.472

0.4610 ± 0.6380

0.8660 ± 00.686

0.8880 ± 0.710

0.6010 ± 0.6850

CSF PTAU pg/mL

19.423 ± 6.820

25.640 ± 11.703

35.2240 ± 13.20

35.717 ± 13.11

28.5940 ± 13.29

CSF TAU pg/mL

215.07 ± 67.28

270.861 ± 106.4

352.86 ± 116.27

361.2 ± 121.41

296.46 ± 120.58

ADAS-Cog 11

05.617 ± 2.784

8.6260 ± 3.5200

13.412 ± 4.3850

19.318 ± 6.569

11.576 ± 06.970

ADAS-Cog 13

08.600 ± 4.108

13.791 ± 05.303

21.580 ± 05.841

29.706 ± 7.835

18.129 ± 10.085

RAVLT immediate

045.595 ± 9.64

37.705 ± 10.308

27.444 ± 06.510

22.466 ± 7.069

33.750 ± 12.585

RAVLT learn

06.139 ± 2.143

04.799 ± 02.403

02.853 ± 02.219

01.799 ± 1.810

3.9770 ± 02.752

RAVLT forgetting

03.582 ± 2.810

04.343 ± 02.497

05.039 ± 02.193

04.381 ± 1.783

4.2930 ± 02.420

RAVLT % forget

32.612 ± 27.53

50.000 ± 30.027

78.188 ± 27.892

88.562 ± 21.22

61.223 ± 35.098

CDR-SB

0.0390 ± 0.141

1.1970 ± 0.6390

02.004 ± 0.9980

04.347 ± 1.591

01.856 ± 01.896

GDTOTAL

0.7890 ± 1.056

1.7090 ± 01.462

01.668 ± 01.423

01.634 ± 1.454

01.423 ± 01.404

HCI

8.9500 ± 3.330

11.066 ± 04.080

15.560 ± 04.770

21.158 ± 7.384

14.048 ± 06.996

Hippo. vol. (cm3) (/1000)

7.4520 ± 0.920

07.106 ± 01.074

06.083 ± 01.038

05.713 ± 0.995

06.621 ± 01.240

  1. AD, Alzheimer’s disease; MCI, mild cognitive impairment; pMCI-sMCI, progressive MCI – stable MCI; CN, cognitive normal; CDR, clinical dementia rating; ADAS-Cog, Alzheimer’s Disease Assessment Scale–Cognitive Subscale test; RAVLT, Rey Auditory Verbal Learning Test; FAQ, Functional Assessment Questionnaire; MMSE, Mini–Mental State Examination; FDG, sum of mean glucose metabolism uptake in regions of angular, temporal, and posterior cingulate; TAU, CSF level of TAU; Aβ42, CSF level of amyloid β1–42 peptide; HCI, hypometabolic convergence index; AV45, Average AV45 SUVR of frontal, anterior cingulate, precuneus, and parietal cortex relative to the cerebellum; Hippo, Hippocampus; GDTOTAL, Geriatric Depression Scale.
  2. *Data are mean ± standard deviation.
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