Figure 4 | Scientific Reports

Figure 4

From: Oxycodone self-administration activates the mitogen-activated protein kinase/ mitogen- and stress-activated protein kinase (MAPK-MSK) signaling pathway in the rat dorsal striatum

Figure 4

Increased phosphorylation of CREB protein levels in the LgA-H rats. (A) Images of western blot and (B, C) quantification of CREB and pCREB. (B) CREB protein levels show no significant changes. (C) pCREB is significantly increases in LgA-L and LgA-H rats. (D) pCREB/CREB ratios are increased in the LgA-H rats and (E) correlated with amount of oxycodone. (n = 5–6 Sal; n = 6 ShA; n = 5–6 LgA-L; n = 6 LgA-H). Full-length blots are presented in Supplementary Figure S5. Key to statistics: *, ** = p < 0.05, 0.01, respectively, in comparison to Sal rats; #, ## = p < 0.05, 0.01, respectively, in comparison to SHA rats; $$ = p < 0.01 in comparison to LgA-L rats. Statistical analyses are as described in Fig. 2.

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