Figure 1
Overview of the basic approach of the study. (a) Diagram of the overall analytical approach to score a set of differential expression profiles according to a given gene transcription signature. For a given expression dataset, we score each mRNA profile according to an independently-derived transcriptional signature representing the host response to SARS-CoV-2 infection. The scoring basis is on whether the relative differential patterns in the external sample profile, higher versus lower, are broadly similar to the patterns of up- versus down-regulation, respectively, in the SARS-CoV-2 signature. The “t score” signature scoring metric from previous studies is used34,35,36,37. (b) Diagram of the study. We first defined transcriptional gene signatures of SARS-CoV-2 infection, using three different lung cell lines (NHBE, A549, Calu-3)7. We then applied these signatures to examine differential expression profiles from the indicated external transcriptome datasets representing other viruses or diseases, other model systems, or patient samples.
