Figure 1 | Scientific Reports

Figure 1

From: Antifibrotic effect of novel neutrophil gelatinase-associated lipocalin inhibitors in cardiac and renal disease models

Figure 1

(A) Difference in the 3D structure of NGAL as determined by X-rays (1DVF, magenta) and NMR (1NGL, green). The main site is represented by yellow spheres and the two peripheral sites by red and cyan spheres. (B) Interaction of GPZ614741 with the NGAL PPI site. Effects of GP1 (GPZ614741) and GP2 (GPZ058225), at 10 µM, on (C) IL6 and Col I secretion, (D) cellular content of Col I, Col III, fibronectin, and Gal-3, and (E) cell proliferation in hNGAL-treated human cardiac fibroblasts. The full-length gel and bands are included in the Supplementary Fig. 10. *p < 0.05 vs. Control. †p < 0.05 vs. NGAL-treated human cardiac fibroblasts.

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