Figure 6 | Scientific Reports

Figure 6

From: Multiplexed CRISPR-Cas9 system in a single adeno-associated virus to simultaneously knock out redundant clock genes

Figure 6

Circadian body temperature of SCN-targeted mice. (a–d) Representative body temperature profile shown as a double plot over 28 d for control (a), CSAC-Crys- (b), CSAC-Pers- (c), and CSAC-Bmal1- (d) injected mice. Gray indicates periods of constant darkness. (e–h) Chi-square periodogram of body temperature during constant darkness in control (e), CSAC-Crys- (f), CSAC-Pers- (g), and CSAC-Bmal1- (h) injected mice. Gray line indicates the periodogram of an individual mouse. Black line indicates the averaged spectrogram of each group. Red line indicates the significance threshold (n = 4–8 mice per group).

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