Figure 5
Therapeutic effects of Gal3 blockade in vivo. Kaplan–Meier survival curves for mice implanted with SKOV3c344, A2780c344, or MDA-MB-231 tumors are shown. (a) For mice implanted with SKOV3c344 tumors, the median survival time for the untreated group was 49 days (95% CI, 45.3–52.6), while the median survival for the group treated with 14D11 and for the group implanted with MUC16 negative SKOV3 cells was not reached after 56 days when the experiment was terminated (p = 0.001). (b) Average tumor growth for animals implanted with SKOV3 cells. (c) For the group implanted with A2780c344 cells, the median survival time for the untreated group was 22 days (95% CI, 19.6–24.4), while the median survival time for the group treated with 14D11 was 31 days (95% CI, not estimable), and median survival was not reached for animals implanted with MUC16 negative A2780 cells (p = 0.0164). (d) Average tumor growth for animals implanted with A2780 cells.
