Figure 3

Combination of PD-L2 expression with NLRC5 expression and mutation or neoantigen load are sensitive predictors for responses to anti-CTLA-4 therapy. (a) Scatterplots for NLRC5 and PD-L2 expression with mutation load (left panel) or neoantigen load (right panel) for response (n = 13) and nonresponse (n = 22) groups. (b) ROC curves for logistic regression models using the respective combination of PD-L2 expression, NLRC5 expression, mutation load and neoantigen load. The numbers with arrow are showing false positive rate with 100% sensitivity. AUC (area under the curve) ± SE (standard error) is depicted.