Table 2 Univariable logistic regression for the outcome “severe versus mild”.

From: Complement C3 identified as a unique risk factor for disease severity among young COVID-19 patients in Wuhan, China

Variable

All patients

Young patients (< = 60 years)

Elderly patients (> 60 years)

Odds ratio [CI]

Adj. p

Odds ratio [CI]

Adj. p

Odds ratio [CI]

Adj. p

ALB (g/L)

0.9320 [0.9109, 0.9530]

< 0.0001

0.9501 [0.9170, 0.9831]

0.0317

0.9211 [0.8900, 0.9521]

< 0.0001

ANC

1.1055 [1.0549, 1.1611]

0.0002

1.0794 [0.9937, 1.1773]

0.2062

1.1032 [1.0408, 1.1741]

0.0062

AST (U/L)

1.0100 [1.0048, 1.0158]

0.0011

1.0062 [1.0005, 1.0130]

0.1762

1.0153 [1.0066, 1.0251]

0.0059

BUN (mmol/L)

1.1116 [1.0658, 1.1661]

< 0.0001

1.0461 [0.9923, 1.1270]

0.3516

1.1324 [1.0730, 1.2051]

0.0002

CK (U/K)

1.0023 [1.0011, 1.0036]

0.0011

1.0021 [1.0005, 1.0042]

0.0926

1.0023 [1.0007, 1.0041]

0.0196

Complement C3 (g/L)

2.0055 [0.6022, 6.9684]

0.3699

15.5808 [2.4111, 122.2841]

0.0392

0.3323 [0.0478, 1.9321]

0.3700

Cr (μmol/L)

1.0076 [1.0035, 1.0122]

0.0017

1.0046 [0.9979, 1.0121]

0.3963

1.0083 [1.0030, 1.0143]

0.0114

CRP

1.0119 [1.0079, 1.0161]

< 0.0001

1.0122 [1.0043, 1.0209]

0.0317

1.0110 [1.0064, 1.0161]

0.0001

D-Dimer (mg/L)

1.0808 [1.0386, 1.1358]

0.0017

1.0580 [0.9368, 1.2306]

0.6455

1.0770 [1.0319, 1.1374]

0.0078

LDH (U/L)

1.0027 [1.0018, 1.0038]

< 0.0001

1.0026 [1.0011, 1.0043]

0.0317

1.0027 [1.0015, 1.0040]

0.0002

LYM (109/L)

0.5842 [0.4926, 0.6908]

< 0.0001

0.5947 [0.4664, 0.7536]

0.0009

0.6016 [0.4698, 0.7662]

0.0003

Myohemoglobin (ng/mL)

1.0054 [1.0027, 1.0091]

0.0023

1.0022 [0.9918, 1.0134]

0.7994

1.0055 [1.0026, 1.0096]

0.0078

PLR

1.0015 [1.0006, 1.0024]

0.0040

1.0008 [0.9996, 1.0022]

0.3963

1.0017 [1.0005, 1.0031]

0.0196

Ratio of CRP versus ALB

1.3836 [1.2341, 1.5667]

< 0.0001

1.3994 [1.0999, 1.8321]

0.0430

1.3393 [1.1759, 1.5467]

0.0002

Ratio of neutrophil versus lymphocyte

1.1061 [1.0687, 1.1485]

< 0.0001

1.0835 [1.0256, 1.1539]

0.0416

1.1105 [1.0629, 1.1666]

0.0001

RBC (1012/L)

0.7775 [0.6493, 0.9287]

0.0140

0.9856 [0.7644, 1.2707]

0.9337

0.6592 [0.5018, 0.8600]

0.0078

SAA (mg/L)

1.0065 [1.0032, 1.0100]

0.0006

1.0066 [1.0023, 1.0112]

0.0317

1.0059 [1.0008, 1.0114]

0.0639

SII

1.0003 [1.0002, 1.0004]

< 0.0001

1.0003 [1.0001, 1.0006]

0.0430

1.0003 [1.0001, 1.0004]

0.0063

  1. The p values were adjusted for multiple testing separately for the analysis of all patients, young patients, and elderly patients.
  2. Increased levels of complement C3 and SAA were associated with an increased risk for severity only in the young patient cohort. Supplementary Table 1 contains the results for all covariates.
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