Figure 5 | Scientific Reports

Figure 5

From: Transcriptional response to the host cell environment of a multidrug-resistant Mycobacterium tuberculosis clonal outbreak Beijing strain reveals its pathogenic features

Figure 5

Intracellular survival odds of the MKR superspreader and H37Rv upon the treatments of V-59, aripiprazole, manidipine and ethoxzolamide. (a–d) THP-1 cells were infected with mCherry-expressing MKR superspreader or H37Rv for 30 min, and were treated with media containing various concentrations of (a) V-59, (b) aripiprazole, (c) manidipine and (d) ethoxzolamide for 3 days. Cells were then fixed and processed for high-content image analysis to quantify the number of mycobacteria per host cell. Percent mycobacterial survival at each concentration was calculated relative to that of the non-treated control group set to 100%. Two-way ANOVA with Bonferroni post-tests were used to determine if the intracellular survival levels were significantly different from that of the control group (*: p < 0.05; **: p < 0.01; and ***: p < 0.001).

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