Figure 4 | Scientific Reports

Figure 4

From: Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects

Figure 4

Intracellular ROS formation. (A) Intracellular ROS (H2DCFDA mean intensity) generated after 72 h of exposure to methotrexate (10 µM), alone or in combination with TH5487 (10 µM) in U2OS cells, (B) BJ-TERT, (C) NTUB1 or (D) HCT116 cells. 10 µM of TH5487 were used in combination with methotrexate for all the cell lines, except for NTUB1 where 5 µM of TH5487 were used. Data are average and SEM of single measurements from 2 independent experiments. Statistics were excluded from this analysis due to the low amount of data points to establish relevant comparisons between groups.

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