Table 1 ZIP synergy scores for conventional chemotherapeutic drugs or BER inhibitors in combination with TH5487.

From: Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects

Cell line

Methotrexate

Doxorubicin

5-Fluoracil

APE1i

PARPi

Cisplatin

HCT116

10.77

4.97

5.33

3.55

3.09

2.84

NTUB1

48.56

5.84

− 3.09

3.05

3.28

− 14.97

U2OS

11.36

2.891

0.5

− 2.57

1.97

− 13.28

BJ-TERT

21

5.88

–

–

− 7.46

–

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