Figure 1 | Scientific Reports

Figure 1

From: Eliciting the silent lucensomycin biosynthetic pathway in Streptomyces cyanogenus S136 via manipulation of the global regulatory gene adpA

Figure 1

taken from 120 h old ISP5 lawns of S. cyanogenus ΔlanI7 (1), S. cyanogenus ΔlanI7 pGM4181d+ (2) and S. cyanogenus ΔlanI7 pGM4181+(3). (d) LC–MS analysis of the secondary metabolites produced in liquid YMPG medium by S. cyanogenus ΔlanI7 pGUSmoeE5script+ (control) and S. cyanogenus ΔlanI7 pGM4181d+; four new mass peaks appeared in the chromatogram for the latter strain.

The adpA gene activates silent secondary metabolome of S. cyanogenus. (a) Phenotypes of S. cyanogenus ΔlanI7 (1), S. cyanogenus ΔlanI7 pGM4181d+ (2; DBD of adpA) and S. cyanogenus ΔlanI7 pGM4181+(3; full-length adpA) after 168 h of growth on TSB agar; B. cereus (b) and D. hansenii (c) growth inhibition assays using agar plugs

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