Figure 6 | Scientific Reports

Figure 6

From: Eliciting the silent lucensomycin biosynthetic pathway in Streptomyces cyanogenus S136 via manipulation of the global regulatory gene adpA

Figure 6

Proposal for the AdpA-mediated regulation of Lcm and the landomycin A biosynthetic pathways in S. cyanogenus. Both biosynthetic pathways compete for PKS precursor supply. AdpA, presumably through direct binding to the lcmRIII promoter region, activates the expression of this lcm cluster-situated transcriptional regulator. Both LcmRII and LcmRIII are positive regulators of Lcm production. The role of LcmRI in the regulation of the Lcm biosynthesis is unclear and awaits further investigations.

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