Figure 1
From: Estimation of three-dimensional chromatin morphology for nuclear classification and characterisation
Pipeline to classify cellular phenotypic states and measure chromatin patterns. Cells are segmented and cropped, followed by extraction of cellular texture features using proposed 3D SRP. Image-based classification is performed using the linear model trained on extracted features. Following classification, heterochromatin intensity and aggregation is measured using the proposed 3D SRP. The presented model is evaluated on publicly available 3D image datasets of human fibroblast and human prostate cancer cells.
