Table 2 Associations of HLA class II genes in individuals with a high response (HBsAb > 100 mIU/mL) to Heptavax-II and Bimmugen vaccines.

From: Importance of HBsAg recognition by HLA molecules as revealed by responsiveness to different hepatitis B vaccines

Haplotype/allele

Heptavax-II

Bimmugen

Chi P

OR

95% CI

Count

%

Count

%

Lower

Upper

DRB1*01:01-DQB1*05:01

41

6.7

97

7.1

7.78E−01

0.95

0.65

1.38

DRB1*04:05-DQB1*04:01

105

17.2

166

12.1

2.22E−03

1.51

1.16

1.97

DRB1*08:03-DQB1*06:01

47

7.7

139

10.1

8.73E−02

0.74

0.52

1.05

DRB1*09:01-DQB1*03:03

98

16.1

183

13.3

1.08E−01

1.24

0.95

1.62

DRB1*13:02-DQB1*06:04

17

2.8

93

6.8

3.40E−04

0.39

0.23

0.67

DRB1*15:01-DQB1*06:02

42

6.9

116

8.5

2.34E−01

0.80

0.55

1.16

DRB1*15:02-DQB1*06:01

78

12.8

139

10.1

8.05E−02

1.30

0.97

1.75

DPB1*02:01

130

23.4

342

24.9

4.75E−01

0.92

0.73

1.16

DPB1*03:01

31

5.6

69

5.0

6.24E−01

1.12

0.72

1.72

DPB1*04:02

54

9.7

156

11.4

2.90E−01

0.84

0.60

1.16

DPB1*05:01

238

42.8

525

38.3

6.48E−02

1.21

0.99

1.48

DPB1*09:01

57

10.3

128

9.3

5.33E−01

1.11

0.80

1.54

  1. The estimated DRB1-DQB1 haplotype frequencies over 5.0% and DPB1 allele frequencies over 5.0% in individuals vaccinated with Bimmugen are shown. The total number of high-responders in Heptavax-II and Bimmugen was 278 and 686, respectively, for the DPB1 allele and 305 and 686, respectively, for the DRB1-DQB1 haplotype. Significance level (α) in HLA association analysis was determined by the sorting test, with P < 0.00368 for the DRB1-DQB1 haplotype and P < 0.00820 for the DPB1 allele. P values and odds ratios (OR) were calculated by Pearson’s chi-square test for presence vs. absence of each allele. P values and OR that were statistically significant after correction are indicated in bold.
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