Figure 6 | Scientific Reports

Figure 6

From: BKM120 sensitizes BRCA-proficient triple negative breast cancer cells to olaparib through regulating FOXM1 and Exo1 expression

Figure 6

Effects of BKM120 and olaparib on the PI3K/Akt /FOXM1/Exo1 signaling pathway. Effects of BKM120, olaparib, and a combination of BKM120 with olaparib on the expressions of FOXO1, FoxO3a, FOXM1 and Exo1 in MDA-MB-231 cells analyzed by (A) RT-PCR and (C) western blots. (E) Effects of drugs on the phosphorylation of FOXO1 and FoxO3a analyzed by western blots. Relative intensity expression obtained from the corresponding (B) RT-PCR and (E,F) western blots. Error bars represent SEM from the mean of three separate experiments. *P < 0.05 and **P < 0.01 compared to control, #P < 0.05 and ##P < 0.01 compared to 19.2 μΜ olaparib-treated group.

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