Figure 8 | Scientific Reports

Figure 8

From: BKM120 sensitizes BRCA-proficient triple negative breast cancer cells to olaparib through regulating FOXM1 and Exo1 expression

Figure 8

Mechanism for the synergistic effects of BKM120 and olaparib on the death of MDA-MB-231 cells. BKM120 directly induces DNA damage through increasing cellular ROS. Meanwhile, BKM120 downregulates the expression of PARP1 and PARP2 to synergy the inhibition of olaparib in the repair of DNA single damage. Moreover, BKM120 inhibits the HR repair of DNA double damage to sensitize cells to olaparib through regulation the PI3K/Akt/NFĸB/c-Myc pathway and PI3K/Akt/ /FOXM1/Exo1 pathway.

Back to article page