Figure 3 | Scientific Reports

Figure 3

From: Novel TLR 7/8 agonists for improving NK cell mediated antibody-dependent cellular cytotoxicity (ADCC)

Figure 3

ADCC assay with human PBMCs (LDH based readout). 558, 543, 574 (1 μM) improved cetuximab-mediated ADCC. Percentage cytotoxicity depicted in figure. (****P < 0.0001 for cetuximab v/s cetuximab + 558/543/574 at Effector:Target ratio 20:1, P < 0.001 for cetuximab v/s cetuximab + 558/543 at Effector:Target ratio 10:1, P < 0.05 for cetuximab v/s cetuximab + 574; two-way ANOVA with multiple comparisons).

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