Figure 1
From: High levels of 27-hydroxycholesterol results in synaptic plasticity alterations in the hippocampus
Altered Shaffer collateral-CA1 Long-term Potentiation (LTP) in Cyp27Tg mice. (A) Representative fEPSP traces before Ø-burst (gray traces) and 60 min after (black and turquoise traces). (B) Time-course of changes in field EPSP (fEPSP) slopes after induction of LTP show an increase in the magnitude of LTP induced by theta-burst (Ø-burst) stimulation in Cyp27Tg mice compared to WT hippocampal mouse slices. (C) Cyp27Tg mice (n = 5 slices/4 mice) showed significantly enhanced LTP compared to WT (n = 5 slices/3 mice) measured 55 to 60 min after Ø-burst relative to baseline; *p = 0.03 by unpaired Mann–Whitney test. Data are represented as the mean ± S.E.M.
