Figure 4
From: High levels of 27-hydroxycholesterol results in synaptic plasticity alterations in the hippocampus
Dendritic spines from CA1 apical dendrites are larger in Cyp27Tg than in WT mice. Comparative morphometric analysis of spine length (A−C, G−I) and spine volume (D−F,J−L) for CA1 LY-injected pyramidal neurons in WT and Cyp27Tg mice for both basal (A−F) and apical (G–L) dendrites. Data are shown as average per dendrite (A,D,G and J; Unpaired Mann–Whitney test), as a function of the distance from the soma (B,E,H and K, Two-way ANOVA repeated measures followed by a post-hoc multiple Bonferroni test) and frequency distribution (C,F,I and L; Kolmogorov–Smirnov test). All data are represented as mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.
