Table 1 Summary of optical absorption and scattering properties at baseline, end-of-asphyxia and 10-min of CPR.

From: Non-invasive diffuse optical neuromonitoring during cardiopulmonary resuscitation predicts return of spontaneous circulation

 

Baseline

n = 48

Asphyxia, End

(Δ Baseline)

p value†

CPR, 10 min (Δ Baseline)

ROSC

n = 37

No-ROSC n = 11

p value‡

Optical absorption coefficient µa (λ), (1/cm)

µa (690 nm)

0.16

[0.14, 0.19]

+ 0.07

[0.05, 0.09]

< 0.001

+ 0.05

[0.03, 0.06]

+ 0.03

[0.02, 0.05]

0.294

µa (725 nm)

0.14

[0.12, 0.15]

+ 0.04

[0.03, 0.05]

< 0.001

+ 0.03

[0.02, 0.04]

+ 0.02

[0.00, 0.03]

0.105

µa (785 nm)

0.14

[0.13, 0.15]

+ 0.02

[0.01, 0.03]

< 0.001

+ 0.01

[0.01, 0.02]

− 0.02

[− 0.02, 0.00]

0.011

µa (830 nm)

0.15

[0.13, 0.16]

+ 0.00

[− 0.01, 0.00]

0.061

+ 0.00

[− 0.00, 0.01]

− 0.01

[− 0.04, − 0.00]

0.001

Optical reduced scattering coefficient µs (λ), (1/cm)

µs′ (690 nm)

10.9

[9.9, 11.8]

+ 0.0

[− 0.4, 0.4]

0.759

− 0.0

[− 0.6, 0.4]

+ 0.3

[− 0.4, 0.6]

0.233

µs′ (725 nm)

10.2

[9.2, 10.9]

+ 0.1

[− 0.2, 0.2]

0.320

− 0.2

[− 0.5, 0.4]

+ 0.1

[− 0.2, 0.4]

0.204

µs′ (785 nm)

9.3

[8.3, 10.2]

+ 0.1

[− 0.1, 0.5]

0.024

− 0.1

[− 0.4, 0.1]

+ 0.5

[0.3, 0.9]

0.005

µs′ (830 nm)

8.7

[7.9, 9.4]

+ 0.0

[− 0.1, 0.2]

0.339

− 0.2

[− 0.5, 0.2]

+ 0.1

[0.0, 0.4]

0.077

Mie scattering model fit parameters, µs′(λ) = a*(λ/500 nm)^b

a, (1/cm)

15.4

[12.1, 18.8]

+ 0.2

[− 1.3, 1.5]

0.604

− 0.44

[− 1.89, 1.47]

+ 0.59

[− 1.23, 1.63]

0.691

b

1.1

[0.7, 1.6]

+ 0.0

[− 0.2, 0.2]

0.837

+ 0.04

[− 0.24, 0.30]

− 0.02

[− 0.20, 0.16]

0.691

Goodness-of-fit (adjusted R2)

0.82

[0.54, 0.94]

− 0.02

[− 0.10, 0.05]

0.142

− 0.03

[− 0.22, 0.05]

+ 0.08

[0.01, 0.17]

0.026

  1. Values summarized as median [IQR].
  2. p value from Wilcoxon signed-rank test.
  3. p value from Wilcoxon rank-sum test comparing ROSC and No-ROSC groups.
  4. λ, wavelength; Δ Baseline, change from Baseline; ROSC, return of spontaneous circulation; a, fitted reduced scattering coefficient at λ = 500 nm; b, scattering power.