Table 3 Predictive performance and optimal decision threshold for significant cerebral hemodynamic parameters.

From: Non-invasive diffuse optical neuromonitoring during cardiopulmonary resuscitation predicts return of spontaneous circulation

Significant parameters

AUC (95% CI)

Jw

Decision threshold

10-fold cross-validation

Decision threshold

[Min, Max]

Jw

Median [IQR]

[HbO2], µmol/L

0.68 (0.50, 0.82)

0.86

31.4

[30.2, 33.4]

0.83 [0.80, 0.87]

Δ[HbO2] from 1 min-CPR

0.94 (0.83, 0.98)

0.96

+ 1.3

[+ 1.3, + 1.9]

0.95 [0.93, 1.00]

r[HbO2] to 1 min-CPR, %

0.91 (0.76, 0.97)

0.90

121.5

[105.5, 121.9]

0.90 [0.87, 0.90]

StO2, %

0.70 (0.50, 0.85)

0.84

45.5

[44.2, 46.2]

0.80 [0.80, 0.83]

ΔStO2 from 1 min-CPR

0.92 (0.81, 0.97)

0.95

+ 2.1

[+ 1.9, + 2.4]

0.94 [0.93, 0.95]

rStO2 to 1 min-CPR, %

0.90 (0.74, 0.97)

0.90

114.7

[105.3, 115.3]

0.87 [0.80, 0.93]

THC, µmol/L

0.59 (0.38, 0.78)

0.81

95.8

[93.2, 95.8]

0.80 [0.80, 0.80]

ΔTHC from 1 min-CPR

0.83 (0.66, 0.93)

0.89

+ 3.4

[+ 2.3, + 3.6]

0.88 [0.86, 0.94]

rTHC to 1 min-CPR, %

0.80 (0.60, 0.91)

0.85

108.1

[104.0, 109.6]

0.80 [0.38, 0.82]

  1. AUC = area under curve of receiver-operating-characteristic; Jw = maximum weighted Youden J index; [HbO2] = oxy-hemoglobin concentration; StO2 = tissue oxygen saturation; THC = total hemoglobin concentration; Δ-prefix = absolute change; r-prefix = relative value compared to 100% at baseline.
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