Table 1 Physicochemical properties of investigated particles: size distribution, zeta-potential, PDI, and entrapment efficacy of PLA/MMT/TRA, PLA/EDTMP, PLGA/MDP, and Pluronic F127 Ms.

From: Disturbance of cellular homeostasis as a molecular risk evaluation of human endothelial cells exposed to nanoparticles

Nanoparticles

Application

NP sizea (nm)

ζ potential (meV)

PDI

Entrapment efficacy (% of drug)

PLA/MMT/TRA

Monoclonal antibodies against HER-2 receptors, used in breast cancer treatment, high cardiotoxicity

278 ± 4.2

0.4 ± 0.6

0.21

90

PLA /EDTMP

Part of technetium izotope 99mTc complex, used in scintigraphy for bone fracture research

265.9 ± 2.8

0.2 ± 0.1

0.19

70

PLGA/MDP

Component of Quadramet medicament used in bone cancer treatment, very toxic to bone marrow

207 ± 2.4

4.6 ± 1.5

0.27

78

Pluronic F127 ms

Applied as basis components for cosmetics and dermatology drugs, mostly to increase UV protection

140 ± 1.2

7.9 ± 0.2

0.3

100

  1. aThe size from each nanosystem has been confirmed by TEM or AFM analysis and the results were similar with the DLS analysis.
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