Table 2 CNA region summaries of FFPE/EV samples for each patient, with overlapped CNA regions (in both number of regions and number of basepairs), with correlation value (r) and p values.

From: Low-coverage whole-genome sequencing of extracellular vesicle-associated DNA in patients with metastatic cancer

Study ID

Tumor

CNA regions (number of region/basepair)

Overlapped CNA region (number of region/basepair)

Correlation value (r =)

Regions with significant deletion/duplication

FFPE

EV

FFPE

EV

B005

mBOT SCC HPV + 

50

2.6 × 109

16

6.2 × 108

7 6 × 108

− 0.49 (p = 0.31)

Deletion: 3p and 8p

Duplication: 3q, 5p and 8q, 20p, 20q

Deletion: 15p

Duplication: 7q, 14q and 15q

B010

mBOT SCC

HPV + 

17

1.1 × 109

11

4.2 × 108

2

1.6 × 108

0.98 (p = 0.41)

Deletion: 1q

Duplication: 8q, 11q, 20q

Deletion: 1q, 4p, 6q

Duplication: 1q, 8q, 14q, 17q

B014

mBOT SCC

HPV −

27

2.5 × 109

7

2.9 × 108

0

2.2 × 108

− 0.08 (p = 0.48)

Deletion: 11q, 14q

Duplication: 3q

Deletion: 15q

Duplication: 5q14p

C004

mcSCC

30

1.7 × 109

19

9.5 × 108

11

5.1 × 108

0.88 (p = 0.19)

Deletion: 8p

Duplication: 7p, 8q, 20p

Deletion: 8p

Duplication: 1p, 3p, 15q, 17q, 20q

C008

mcSCC

28

1.6 × 109

31

1.5 × 109

21

1.4 × 109

0.42 (p = 0.86)

Deletion: 4q, 9p, 11q

Duplication: 7p, 8q, 9q, 14q, 20p

Deletion: 2q, 4q, 6q, 8p, 11q

Duplication: 5p, 14q, 15q

  1. mBOT SCC metastatic base of tongue squamous cell carcinoma, mcSCC metastatic cutaneous squamous cell carcinoma.