Table 3 Plasma levels and C/D of RIS, 9-OH-RIS, active moiety, and RIS/9-OH-RIS ratio among CYP2D6 activity scores groups (n = 199).
AS | n (%) | RIS (ng/ml) | 9-OH-RIS (ng/ml) | Active moiety (ng/ml) | Ratio of RIS/9-OH-RIS | C/D of RIS (ng/ml/mg) | C/D of 9-OH-RIS (ng/ml/mg) | C/D of active moiety (ng/ml/mg) |
|---|---|---|---|---|---|---|---|---|
AS = 0 | 1 (0.50) | 2.67 | 1.78 | 4.45 | 1.50 | 10.68 | 7.12 | 17.80 |
AS = 0.25 | 17 (8.54) | 1.43 (0.68–4.20)a | 5.11 (3.86–13.56) | 8.17 (4.53–22.95) | 0.35 (0.17–0.82)a | 1.45 (0.82–4.77)a | 5.50 (3.86–8.00)d | 9.01 (5.47–16.34) |
AS = 0.5 | 55 (27.64) | 1.10 (0.35–2.54)a | 5.32 (3.11–11.40) | 6.11 (4.54–11.96) | 0.19 (0.06–0.35)a | 1.48 (0.34–2.73)a | 8.13 (5.42–11.93) | 10.23 (6.32–14.39) |
AS = 0.75 | 15 (7.54) | 1.61 (0.92–2.58)a | 5.13 (3.78–7.45) | 7.25 (5.28–9.76) | 0.26 (0.19–0.35)a | 2.24 (1.52–3.71)a | 10.15 (6.33–16.00) | 11.68 (7.83–19.87) |
AS = 1.0 | 17 (8.54) | 0.44 (0.05–1.20) | 7.56 (2.71–11.63) | 7.56 (2.79–12.83) | 0.05 (0.02–0.11) | 0.27 (0.19–2.40) | 10.90 (6.68–21.40) | 11.79 (6.81–21.48) |
AS = 1.25 | 70 (35.18) | 0.33 (0.05–0.74) | 7.27 (4.30–11.23) | 7.60 (4.31–12.78) | 0.04 (0.02–0.08) | 0.36 (0.15–0.99) | 9.18 (6.74–14.13) | 9.72 (6.74–15.05) |
AS = 1.5 | 9 (4.52) | 0.13 (0.05–0.49) | 2.28 (1.44–9.75) | 4.19 (1.44–9.88) | 0.05 (0.04–0.07) | 0.40 (0.10–0.61) | 6.74 (2.88–8.45) | 8.38 (2.88–9.06) |
AS = 2.0 | 15 (7.54) | 0.05 (0.02–0.27) | 8.36 (6.36–12.87) | 8.36 (6.71–13.61) | 0.01 (0.00–0.03) | 0.05 (0.03–0.49) | 7.95 (5.28–19.45) | 8.08 (5.33–21.13) |
