Figure 1

Flow diagram for selection of the study participants. We excluded the following participants: (1) 54 participants whose amyloid PET result changed from positive to negative; (2) 40 participants in whom ADAS-cog13 scores were obtained only once; (3) 445 participants with amyloid-negative PET results, because if amyloid-negative CN could become amyloid-positive, it would be difficult to create a disease progression model with amyloid-negative MCI; and (4) 116 participants with dementia at baseline, because their follow-up was short and the ADAS-cog 13 scores of AD dementia participants were in the range of the ADAS-cog 13 scores of participants who progressed from MCI due to AD to AD dementia. ADAS-cog: Alzheimer's Disease Assessment Scale-cognitive subscale, CN: cognitive normal; MCI: mild cognitive impairment; AD: Alzheimer's Disease.