Figure 3
From: Disease progression modelling from preclinical Alzheimer’s disease (AD) to AD dementia
Disease progression model from preclinical AD to AD dementia. The curves present the estimated model—ADAS-cog 13 = (2.8492 + 0.0130 × month)2 – 0.5 and its 95% CI and the plots show preclinical AD (green dots), progression to MCI due to AD (yellow dots), MCI due to AD (blue dots), and progression to AD dementia (red dots). Using the median ADAS-cog 13 scores at the time of progression for individuals who progressed from preclinical AD to MCI due to AD (16.0 points) and from MCI due to AD to AD dementia (26.8 points), we estimated the time for preclinical AD to progress to MCI due to AD (7.8 years) and to AD dementia (15.2 years). When using the median ADAS-cog 13 scores for late MCI (19.0 points) to estimate time to progression, it took 8.9 years for preclinical AD to progress to late MCI. ADAS-cog: Alzheimer's Disease Assessment Scale-cognitive subscale; MCI: mild cognitive impairment; AD: Alzheimer's Disease; CI: Confidence interval.
