Table 3 Incidence of most frequent adverse events.

From: Real-world data of fulvestrant as first-line treatment of postmenopausal women with estrogen receptor-positive metastatic breast cancer

Adverse event

Number of patients (%)

Musculoskeletal and connective tissue disorders

53 (38.1)

Asthenia

48 (34.5)

Injection site reactions

30 (21.6)

Nausea

18 (12.9)

Decreased appetite

18 (12.9)

Diarrhea

15 (10.8)

Headache

13 (9.4)

Dyspnea

13 (9.4)

Peripheral neuropathy

11 (7.9)

Palmar-plantar erythrodysesthesia syndrome

11 (7.9)

Vomiting

10 (7.2)

Abdominal pain—upper

8 (5.8)

Neutropenia

7 (5.0)

Constipation

7 (5.0)

Rash

7 (5.0)

Hot flush

7 (5.0)