Figure 5
Summary of findings. In EDiPS animals, the increase in AMPH-induced hyperlocomotion is evident from 6 weeks following administration of the EDiPS construct at P35. In contrast, the PPI deficit is apparent from 4 weeks following administration of the construct. No difference in the response to stress is seen over this time. This progression of behavioural phenotypes likely reflects an increasing dysfunction of dopaminergic activity in the dorsal striatum, induced by the EDiPS construct. This parallels the increase in dopaminergic dysfunction which appears to contribute to the transition in patients from the prodromal stage of schizophrenia to expression of the full disorder.
