Table 3 Interactions between individual single nucleotide polymorphisms (SNPs) and 7 environmental factors. aChromosomal positions are based on the 1000 Genomes Project’s haplotype phase 1 in NCBI build 37 (hg19). bMAF is minor allele frequency. cThe P value for the effects of interaction between genotypes and environmental factors on BMI were assessed by using a Struct-LMM with adjustment for age, sex, and recruitment area.
Chromosome | Nearest gene | SNP ID | Positiona | Minor allele | Major allele | MAFb (%) | P valuec |
|---|---|---|---|---|---|---|---|
1 | GJB5 | rs12402440 | 34,968,257 | G | T | 20.91 | 4.02 × 10−6 |
1 | C1orf110 | rs12405096 | 162,926,260 | T | C | 41.78 | 4.60 × 10−6 |
1 | RAB3GAP2* | rs74565497 | 220,415,930 | G | A | 8.12 | 4.82 × 10−6 |
3 | LOC100288428 | rs59756727 | 8,242,302 | A | T | 44.08 | 1.81 × 10−7 |
6 | SNRNP48 | rs7760212 | 7,656,037 | A | G | 32.02 | 8.62 × 10−7 |
8 | MSRA* | rs117301188 | 10,070,612 | A | C | 9.62 | 4.70 × 10−6 |
8 | RSPO2* | rs7833349 | 108,966,199 | T | C | 24.70 | 3.81 × 10−6 |
13 | MTIF3 | rs9512706 | 28,041,615 | A | C | 19.87 | 2.91 × 10−6 |
13 | EFNB2* | rs2391331 | 107,157,709 | C | T | 42.90 | 7.27 × 10−9 |
19 | ZNF787 | rs668056 | 56,595,733 | T | C | 28.74 | 2.87 × 10−6 |
22 | ISX | rs5755279 | 35,186,350 | G | A | 23.91 | 4.65 × 10−6 |
