Figure 4
From: Inverse relation between structural flexibility and IgE reactivity of Cor a 1 hazelnut allergens
Hydrogen–deuterium exchange in Cor a 1.04 isoforms. (a) Time-dependent SOFAST 1H–15N-HMQC backbone amide intensities (circles), recorded at 10 °C, are shown for representative residues with drastically faster H/D exchange in Cor a 1.0404 (orange) than in Cor a 1.0401 (blue), along with best-fit exponential curves. (b) Amino acid residues for which H/D exchange is at least four times faster are highlighted in orange on the structure of Cor a 1.0404 (6Y3L). The four exemplary amino acid residues (Ala9, Glu101, Ala107, and Ala154) and Pro99 are displayed as sticks.
