Figure 2

(a–e) Field potential propagation over hiPSC-CM sheet on microelectrode array at baseline before hypoxia, at 8 h and 24 h hypoxia and at 6 h and 24 h reoxygenation. The heatmaps clearly indicate slowing of the field potential conduction during hypoxia, but the conduction velocity is restored during reoxygenation. f) Field potential conduction time from electrode to electrode at baseline, 8 h and 24 h hypoxia, and 6 h and 24 h reoxygenation (mean + standard deviation). Conduction time increased during hypoxia compared to baseline, whereas it was restored close to baseline level during reoxygenation. ***p < 0.001.