Table 5 Median DFI and independent risk factors for metastasis.
Overall DFI | bDFI | |||||
|---|---|---|---|---|---|---|
Median (95%CI) | HR from univariate Cox regression model (95%CI) | HR from multivariate Cox regression model (95%CI) | Median (95%CI) | HR from univariate Cox regression model (95%CI) | HR from multivariate Cox regression model (95%CI) | |
All cases | 75.7 (63.5–87.3) | – | – | 78.2 (63.6–87.9) | – | – |
Age at diagnosis of primary BC, years | ||||||
< 55 | 82.1 (65.4–112.9) | 1.00 | 1.00 | 89.6 (65.4–114.8) | 1.00 | 1.00 |
≥ 55 | 65.0 (48.1–81.5) | 1.91 (1.4–2.7) | 1.48 (0.9–2.2) | 65.0 (51.1–86.0) | 1.89 (1.4–2.6) | 1.27 (0.9–1.9) |
BC molecular subtypes | ||||||
Luminal A | 101.9 (57.0–125.7) | 1.00 | 1.00 | 101.9 (57.0–125.7) | 1.00 | 1.00 |
Luminal B | 63.5 (48.6–75.7) | 1.66 (1.1–2.5) | 1.46 (0.9–2.4) | 63.6 (52.7–78.5) | 1.54 (0.9–2.4) | 1.27 (0.8–2.0) |
Basal-like | 30.0 (13.4–NE) | 3.92 (1.6–9.7) | 3.94 (1.4–11.0) | 30.0 (2.1–66.1) | 4.29 (1.8–10.1) | 3.82 (1.4–10.6) |
HER2+ | 53.1 (30.9–100.1) | 1.28 (0.7–2.4) | 1.44 (0.7–2.9) | 53.1 (47.9–100.2) | 1.17 (0.6–2.2) | 1.22 (0.6–2.5) |
Stage at diagnosis | ||||||
I | 67.2 (53.1–96.1) | 1.00 | 1.00 | 82.2 (53.6–125.7) | 1.00 | 1.00 |
II | 83.3 (66.5–99.2) | 0.98 (0.6–1.5) | 1.09 (0.5–2.3) | 83.2 (66.5–101.9) | 1.07 (0.7–1.7) | 1.16 (0.6–2.4) |
III | 58.1 (41.9–73.4) | 1.84 (1.1–3.0) | 1.35 (0.5–3.2) | 60.9 (41.9–75.6) | 2.1 (1.3–3.5) | 1.55 (0.7–3.7) |
IV | – | – | – | – | – | – |
pT at primary diagnosis of BC | ||||||
T0–T2 | 76.7 (61.0–87.3) | 1.00 | 1.00 | 78.5 (63.6–87.9) | 1.00 | 1.00 |
T3–T4 | 20.6 (3.3–65.4) | 3.7 (1.9–7.1) | 3.24 (1.5–7.1) | 18.6 (3.3–57.0) | 4.5 (2.4–8.2) | 3.02 (1.4–6.6) |
pN at primary diagnosis of BC | ||||||
N0 | 83.3 (56.1–101.9) | 1.00 | 1.00 | 89.6 (61.1–118.2) | 1.00 | 1.00 |
N+ | 66.5 (56.3–80.0) | 1.36 (0.9–1.9) | 0.91 (0.5–1.7) | 66.5 (57.0–79.0) | 1.47 (1.0–2.1) | 0.97 (0.5–1.8) |
