Figure 8 | Scientific Reports

Figure 8

From: 3D spheroid models of paediatric SHH medulloblastoma mimic tumour biology, drug response and metastatic dissemination

Figure 8

Upregulated genes in the 3D spheroid migration model are associated with poor prognosis and early relapse. The R2 Genomics Analysis and Visualization Platform was used to analyse the Cavalli medulloblastoma dataset. (a) Heatmap showing the k-means clustering of 223 SHH subgroup samples into two groups (cluster 1: n = 125; cluster 2: n = 98) based on the expression of the 500 upregulated genes in the 3D spheroid migration model. (b) Kaplan–Meier overall survival curves for clusters 1 and 2. Pie charts showing the age (c) and SHH subtype (d) distributions in clusters 1 and 2. Kaplan–Meier overall survival curves for the stem cell markers HES5 (e) and JAG1 (f) in SHH medulloblastoma patients (n = 172).

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